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Prescribing Information and adverse events reporting information can be found at the bottom of this page.

This website has been developed and funded by A. Menarini Farmaceutica Internazionale SRL. The Improving Diabetes Steering Committee is supported by an educational grant from A. Menarini Farmaceutica Internazionale SRL. The SGLT2 Inhibitor Prescribing Decision Tool has been independently prepared by the IDSC. The media partners for this activity are GPnotebook and Diabetes on the net. GPnotebook and Diabetes on the net have had no input into the content of this website.

Bridging the gap between type 2 diabetes guidelines and prescribing practices

The Improving Diabetes Steering Committee (IDSC) – a multidisciplinary group of experts across primary and secondary care – aims to support healthcare professionals by producing materials that provide balanced reviews of the evidence and guidelines relating to use of SGLT2 inhibitors in the management of type 2 diabetes, including their risk/benefit profile in reducing the risk of cardiovascular, renal and metabolic (CVRM) complications.

The tools and resources developed by the IDSC and collated in this hub aim to build greater confidence regarding the use of SGLT2 inhibitors in type 2 diabetes management, helping to bridge the gap between current guidelines and prescribing practices.

SGLT2 Inhibitor
Prescribing Decision Tool

Use our evidence-led, interactive SGLT2 Inhibitor Prescribing Decision Tool for a quick reference guide that supports you in making appropriate prescribing decisions in clinical practice.

The handy traffic light system provides clarity regarding common areas of confusion, including the early and late use of SGLT2 inhibitors and complication risk.

Click here to use the SGLT2 Inhibitor Prescribing Decision Tool
Click here to download the wallchart
Click here to request a printed wallchart from Menarini

The SGLT2 Inhibitor Prescribing Decision Tool has been independently prepared by the IDSC. A. Menarini Farmaceutica Internazionale SRL has fully funded the development of the SGLT2 Inhibitor Prescribing Decision Tool wallchart.

Hear from the IDSC

Play Video

Introducing the SGLT2 Inhibitor Prescribing Decision Tool and how to use it in clinical practice

Professor John Wilding

Chair of the Improving Diabetes Steering Committee; Professor of Medicine, University of Liverpool

Jane Diggle

Specialist Diabetes Nurse Practitioner, College Lane Surgery, West Yorkshire

Watch Professor David Wheeler and Jane Diggle walk through the practicalities of the SGLT2 Inhibitor Prescribing Decision Tool for type 2 diabetes management and how you can access the IDSC resources.

Play Video

What are the outputs of the IDSC and how do they benefit people living with type 2 diabetes?

Professor John Wilding

Chair of the Improving Diabetes Steering Committee; Professor of Medicine, University of Liverpool

Join Lisa Kelly as she interviews Professor John Wilding on his role in the IDSC, their previous and most recent outputs, and how the materials they produce aim to benefit both healthcare professionals and people living with type 2 diabetes.

Play Video

How can IDSC initiatives benefit both patients and healthcare providers in primary and secondary care?

Phillip Newland-Jones

Consultant Pharmacist in Diabetes and Endocrinology, University Hospitals Southampton NHS Foundation Trust

Watch Lisa Kelly and Phillip Newland-Jones discuss the importance of concomitant treatment in diabetes and other cardiorenal metabolic diseases, and how the tools developed by the IDSC can help both healthcare professionals and patients with type 2 diabetes.

Play Video

Nephrology and type 2 diabetes: Insights from an IDSC nephrologist

Professor David Wheeler

Professor of Kidney Medicine at UCL & Consultant Nephrologist, The Royal Free, University College London

Hear Lisa Kelly and Professor David Wheeler discuss the latest guideline-based narrative review by the IDSC, and the link between diabetes and kidney disease.

Play Video

Exploring the latest IDSC narrative review on SGLT2 inhibitors and their role in CVRM conditions

Dr Kevin Fernando

GP Partner with Special Interest in Diabetes, North Berwick

Watch Dr Kevin Fernando talk about the impact the IDSC has had over the past six years – from five narrative reviews to evidence- and guideline-based prescribing decision tools.

Play Video

Bringing expertise together: How did the IDSC interdisciplinary team collaborate to create practical tools for type 2 diabetes?

Jane Diggle

Specialist Diabetes Nurse Practitioner, College Lane Surgery, West Yorkshire

Jane Diggle discusses her involvement with the IDSC, and the outputs and impact this interdisciplinary expert group has had in the diabetes landscape.

If you are watching or listening to these videos, please ensure the content cannot be viewed or overheard by the general public

SGLT2 inhibitors: the new standard of care for cardiovascular, renal and metabolic protection in type 2 diabetes – a new narrative review

The IDSC has published five narrative reviews1–5 that reflect the growing evidence surrounding SGLT2 inhibitors in type 2 diabetes and aim to translate these evidence into clinical practice.

The most recent narrative review5 summarises the value of SGLT2 inhibitors in treating cardiovascular, renal and metabolic diseases, and places the relative risks into context.

Click here to read the full review

SGLT2 inhibitors: the new standard of care for CVRM protection in type 2 diabetes – a new narrative review

The IDSC has published five narrative reviews1–5 that reflect the growing evidence surrounding SGLT2 inhibitors in type 2 diabetes and aim to translate this evidence into clinical practice.

The most recent narrative review5 summarises the value of SGLT2 inhibitors in treating CVRM diseases, and places the relative risks into context.

Click here to read the full review

The above link will direct you to a third-party website. A. Menarini Farmaceutica Internazionale SRL and the media partners have had no input into the content of this website.

CVRM: cardiovascular, renal and metabolic; IDSC: Improving Diabetes Steering Committee; SGLT2: sodium-glucose co-transporter-2

Meet the IDSC

John PH Wilding (IDSC CHAIR)

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, UK

Samuel Seidu

Diabetes Research Centre, University of Leicester, Leicester General Hospital, UK

Vicki Alabraba

Leicester Diabetes Centre, University Hospitals Leicester NHS Trust, Leicester, UK

Sarah Davies

Woodlands Medical Centre, Cardiff, UK

Philip Newland-Jones

University Hospitals Southampton NHS Foundation Trust, UK

Kevin Fernando

North Berwick Health Centre, North Berwick, UK

Stephen C Bain

Diabetes Research Group, Swansea University Medical School, Swansea University; Department of Diabetes and Endocrinology, Singleton Hospital, Swansea Bay University Health Board, UK

Jane Diggle

College Lane Surgery, Ackworth, West Yorkshire, UK

Marc Evans

University Hospital Llandough, Cardiff, UK

June James

Leicester Diabetes Centre, University Hospitals Leicester NHS Trust, UK

Naresh Kanumilli

Brooklands Northenden Primary Care Network, Manchester; Manchester University Foundation Trust, UK

Nicola Milne

Brooklands Northenden Primary Care Network, Manchester, UK

Adie Viljoen

Borthwick Diabetes Research Unit, Lister Hospital, Stevenage, UK

David C Wheeler

Professor of Kidney Medicine at UCL & Consultant Nephrologist, The Royal Free, University College London, UK

Amar Ali

Oakenhurst Medical Practice, Blackburn, UK

Debbie Hicks

TREND UK

Dipesh Patel

University College London, London, UK

Jose Luis Górriz

University Hospital Clinic, University of Valencia, Spain

Ana Cebrián

Spanish Diabetes Association, Catholic University of Murcia, Service Murciano de Salud, Cartagena, Murcia; Centro de Salud Casco Antiguo Cartagena, Murcia; Primary Care Research Group, Biomedical Research Institute of Murcia (IMIB), Spain

Stefano Del Prato

University of Pisa, Pisa, Italy

Andra Da Porto

Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, UK

CVRM: cardiovascular, renal and metabolic; IDSC: Improving Diabetes Steering Committee; SGLT2: sodium-glucose co-transporter-2

References

  1. Wilding J, et al. Diabetes Ther. 2018; 9:1757–1773
  2. Ali A, et al. Diabetes Ther. 2019; 10:1595–1622
  3. Wheeler DC, et al. Diabetes Ther. 2020; 11:2757–2774
  4. Wilding JPH, et al. Diabetes Ther. 2022; 13:847–872
  5. Seidu S, et al. Diabetes Ther. 2024; 15:1099–1124

Invokana® (canagliflozin) is indicated for the treatment of adults with insufficiently controlled type 2 diabetes mellitus as an adjunct to diet and exercise:

  • As monotherapy when metformin is considered inappropriate due to intolerance or contraindications
  • In addition to other medicinal products for the treatment of diabetes

Refer to SmPC for full indications.

Click here for Invokana® (canagliflozin) Great Britain Prescribing Information. Click here for Invokana® (canagliflozin) Northern Ireland Prescribing Information.

This website has been developed and funded by A. Menarini Farmaceutica Internazionale SRL. The Improving Diabetes Steering Committee is supported by an educational grant from A. Menarini Farmaceutica Internazionale SRL. The SGLT2 Inhibitor Prescribing Decision Tool has been independently prepared by the IDSC. The media partners for this activity are GPnotebook and Diabetes on the net. GPnotebook and Diabetes on the net have had no input into the content of this website.

Adverse events should be reported. Reporting forms and information can be found at https://yellowcard.mhra.gov.uk/. Adverse events should also be reported to A. Menarini Farmaceutica Internazionale SRL on 0800 085 8678 or by e-mail: [email protected]

PP-IN-UK-1449 | June 2024

A. Menarini Farmaceutica Internazionale SRL have had no input into the contents of the footer and are not affiliated with the links. GPnotebook is responsible for the contents of the footer.

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Prescribing information for Great Britain and Northern Ireland
Adverse events should be reported. Reporting forms and information can be found at https://www.mhra.gov.uk/yellowcard (UK) or https://www.hpra.ie/homepage/about-us/report-an-issue (IRE). Adverse events should also be reported to Boehringer Ingelheim Drug Safety on 0800 328 1627 (freephone) (UK) or 01 2913960 (IRE), Fax: +44 1344 742661, or by e-mail: [email protected].


NICE Technology Appraisal Guidance: Tirzepatide for treating type 2 diabetes10

Tirzepatide is recommended for treating type 2 diabetes alongside diet and exercise in adults when it is insufficiently controlled only if:

  • triple therapy with metformin and 2 other oral antidiabetic drugs is ineffective, not tolerated or contraindicated, and
  • they have a body mass index (BMI) of 35 kg/m2 or more, and specific psychological or other medical problems associated with obesity, or
  • they have a BMI of less than 35 kg/m2, and:
  • insulin therapy would have significant occupational implications, or
  • weight loss would benefit other significant obesity-related complications

Use lower BMI thresholds (usually reduced by 2.5 kg/m2) for people from South Asian, Chinese, other Asian, Middle Eastern, Black African or African-Caribbean family backgrounds.

Reference: 10. © NICE 2023 Tirzepatide for treating type 2 diabetes. Available from https://www.nice.org.uk/guidance/TA924. Accessed March 2024. All rights reserved. Subject to Notice of rights.

NICE guidance is prepared for the National Health Service in England. All NICE guidance is subject to regular review and may be updated or withdrawn. NICE accepts no responsibility for the use of its content in this product/publication.

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